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This is where peptides like KPV become relevant, because they target NF-kB directly

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Many trials assessing intestinal permeability or barrier-related outcomes run 8–12 weeks Epithelial cells renew continuously, but coordinated renewal and signaling patterns take time to stabilize Immune-epithelial interactions become more consistently regulated Reviews of barrier biology emphasize that meaningful modulation typically emerges over weeks to months , not days (Chelakkot et al., 2018)